Singulair (Montelukast)
Singulair is the brand name of montelukast, a drug prescribed for people with asthma.Singulair helps prevent the wheezing and shortness of breath caused by asthma attacks.
Singulair can also help decrease the frequency of asthma attacks, and it may be used to relieve the symptoms of hay fever, allergic rhinitis, and other allergies that cause sneezing and stuffy, runny, or itchy nose.
You can also take it to prevent exercise-induced asthma.
Singulair works by blocking certain natural substances called leukotrienes that may cause or worsen asthma and allergies.
Leukotrienes — chemicals your body releases when you breathe in an allergen, such as pollen — cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.
Singulair is made by Merck and was approved for use by the Food and Drug Administration (FDA) in 1998 for treatment of asthma-related symptoms.
The FDA has approved several generic versions of montelukast, but Singulair continues to be the most popular prescribed brand.
In 2008, the FDA announced that it would investigate whether mood changes and suicidal thoughts were possible side effects of leukotriene modulator drugs, including Singulair.
Clinical trials revealed only an increased risk of insomnia, but surveys showed that the drugs are also associated with a possible increase in suicidal behavior, agitation, aggression, irritability, hallucinations, and depression.